Directorio
MACARENA MARTINEZ BAILEN
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Profesor Ayudante Doctor
Contacto
Correo electrónico
Departamento
ðù±ð²¹
QuÃmica Orgánica
Docencia
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Grupo de investigación
QUÃMICA DE BIOMOLÉCULAS Y ANÃLOGOS (QBA)
Proyectos y contratos de investigación
Diseño y SÃntesis de Moléculas de Interés Biológico Mediante el Desarrollo de MetodologÃas Sintéticas (CTQ2016-77270-R - Investigador/a)
Nuevas Aproximaciones Sintéticas para la Preparación de Moléculas Bioactivas (CTQ2012-31247 - Investigador/a)
Asistencia a congresos
MartÃnez, Macarena;Carmona-Asenjo, Ana Teresa;Angulo-Ãlvarez, Jesús;Matassini, Camilla;Cardona, Francesca;Moreno-Vargas, Antonio José;Robina-RamÃrez, Inmaculada:
Saturation Transfer Difference NMR (STD NMR) as useful tool for the characterization of multimeric pyrrolidine iminosugar binding to GH1 ß-glucosidase. Poster en Congreso. VIII EFMC Young Medicinal Chemists Symposium . Virtual. 2021
Saturation Transfer Difference NMR (STD NMR) as useful tool for the characterization of multimeric pyrrolidine iminosugar binding to GH1 ß-glucosidase. Poster en Congreso. VIII EFMC Young Medicinal Chemists Symposium . Virtual. 2021
MartÃnez, Macarena;Clemente, Francesca;Matassini, Camilla;Goti, Andrea;Cardona, Francesca:
New stereoselective approaches to 8-membered iminosugars. Poster en Congreso. Scuola Avanzata di Chimica dei Carboidrati (XVII CSCC 2021). Certosa di Pontignano - Siena, Italia. 2021
New stereoselective approaches to 8-membered iminosugars. Poster en Congreso. Scuola Avanzata di Chimica dei Carboidrati (XVII CSCC 2021). Certosa di Pontignano - Siena, Italia. 2021
MartÃnez, Macarena;Carmona-Asenjo, Ana Teresa;Matassini, Camilla;Cardona, Francesca;Robina-RamÃrez, Inmaculada;Moreno-Vargas, Antonio José:
Pyrrolidine-based multimeric iminosugars as potent glycosidase inhibitors. Comunicación en congreso. XVI Simposio de Jóvenes Investigadores de la Real Sociedad Española de QuÃmica, RSEQ - Sigma Aldrich (MERCK). Valencia. 2019
Pyrrolidine-based multimeric iminosugars as potent glycosidase inhibitors. Comunicación en congreso. XVI Simposio de Jóvenes Investigadores de la Real Sociedad Española de QuÃmica, RSEQ - Sigma Aldrich (MERCK). Valencia. 2019
Gil De Montes, Enrique;MartÃnez, Macarena;Carmona-Asenjo, Ana Teresa;Robina-RamÃrez, Inmaculada;Moreno-Vargas, Antonio José:
SÃntesis de pirroles y furanos ß-sustituidos a partir de sistemas 7-heteronorbornadiénicos. Comunicación en congreso. 3er Congreso de Estudiantes de Doctorado en QuÃmica. UNIVERSIDAD DE SEVILLA, - FACULTAD DE QUÃMICA. 2019
SÃntesis de pirroles y furanos ß-sustituidos a partir de sistemas 7-heteronorbornadiénicos. Comunicación en congreso. 3er Congreso de Estudiantes de Doctorado en QuÃmica. UNIVERSIDAD DE SEVILLA, - FACULTAD DE QUÃMICA. 2019
MartÃnez, Macarena;Carmona-Asenjo, Ana Teresa;Matassini, Camilla;Cardona, Francesca;Kato, Atsushi;Robina-RamÃrez, Inmaculada;Moreno-Vargas, Antonio José:
Inhibition of lysosomal glycosidases by multimeric presentations of pyrrolidine-based iminosugars. Poster en Congreso. 21st European Symposium of Organic Chemistry. Viena (Austria). 2019
Inhibition of lysosomal glycosidases by multimeric presentations of pyrrolidine-based iminosugars. Poster en Congreso. 21st European Symposium of Organic Chemistry. Viena (Austria). 2019
Robina-RamÃrez, Inmaculada;MartÃnez, Macarena;Galbis-Fuster, Elsa;Carmona-Asenjo, Ana Teresa;Paz-Bañez, Maria Violante De:
Preparation of water-soluble glycopolymers derived from five-membered iminosugars. Poster en Congreso. 20th European Carbohydrate Symposium. Leiden (Holanda). 2019
Preparation of water-soluble glycopolymers derived from five-membered iminosugars. Poster en Congreso. 20th European Carbohydrate Symposium. Leiden (Holanda). 2019
MartÃnez, Macarena;Carmona-Asenjo, Ana Teresa;Lieberman, Raquel;Patterson-orazem, Athena;Kato, Atsushi;Robina-RamÃrez, Inmaculada;Moreno-Vargas, Antonio José:
Halogenated aromatic (pyrrolidin-2yl)triazoles as new pharmacological chaperones for Gaucher disease . Comunicación en congreso. 2º Congreso de Estudiantes de Doctorado en QuÃmica. UNIVERSIDAD DE SEVILLA, - FACULTAD DE QUÃMICA. 2018
Halogenated aromatic (pyrrolidin-2yl)triazoles as new pharmacological chaperones for Gaucher disease . Comunicación en congreso. 2º Congreso de Estudiantes de Doctorado en QuÃmica. UNIVERSIDAD DE SEVILLA, - FACULTAD DE QUÃMICA. 2018
Clemente, Francesca;Matassini, Camilla;MartÃnez, Macarena;Goti, Andrea;Cardona, Francesca:
Stereoselective access to 8 membered iminosugars by means of allylic organometallic reagents additions to a carbohydrate derived aldehyde and osmium c. Poster en Congreso. XXII International Conference on Organic Synthesis. Florencia. 2018
Stereoselective access to 8 membered iminosugars by means of allylic organometallic reagents additions to a carbohydrate derived aldehyde and osmium c. Poster en Congreso. XXII International Conference on Organic Synthesis. Florencia. 2018
Carmona-Asenjo, Ana Teresa;ElÃas-RodrÃguez, Pilar;Pingitore, Valeria;MartÃnez, Macarena;Ide, Daisuke;Kato, Atsushi;Moreno-Vargas, Antonio José;Robina-RamÃrez, Inmaculada:
Discovery of Potent Glycosidase Inhibitors by in situ Analysis of a Library of Hybrid Molecules Generated via Click Chemistry . Comunicación en congreso. 29th International Carbohydrate Symposium. Lisboa (Portugal). 2018
Discovery of Potent Glycosidase Inhibitors by in situ Analysis of a Library of Hybrid Molecules Generated via Click Chemistry . Comunicación en congreso. 29th International Carbohydrate Symposium. Lisboa (Portugal). 2018
MartÃnez, Macarena;Carmona-Asenjo, Ana Teresa;Ide, Daisuke ;Kato, Atsushi;Moreno-Vargas, Antonio José;Robina-RamÃrez, Inmaculada:
Exploring substituent diversity on aromatic (pyrrolidin-2-yl)triazoles: Influence on ß-glucocerebrosidase inhibition . Comunicación en congreso. XXVII Reunión Bienal de QuÃmica Orgánica. . SANTIAGO DE COMPOSTELA. 2018
Exploring substituent diversity on aromatic (pyrrolidin-2-yl)triazoles: Influence on ß-glucocerebrosidase inhibition . Comunicación en congreso. XXVII Reunión Bienal de QuÃmica Orgánica. . SANTIAGO DE COMPOSTELA. 2018
MartÃnez, Macarena;Moreno-Clavijo, Elena;Carmona-Asenjo, Ana Teresa;Moreno-Vargas, Antonio José;Robina-RamÃrez, Inmaculada;Matassini, Camilla;Cardona, Francesca:
SÃntesis y evaluación biológica de pirrolidÃn-2-il-triazoles multiméricos. Comunicación en congreso. I Congreso de Estudiantes de Doctorado en QuÃmica. , UNIVERSIDAD DE SEVILLA, - FACULTAD DE QUÃMICA. 2017
SÃntesis y evaluación biológica de pirrolidÃn-2-il-triazoles multiméricos. Comunicación en congreso. I Congreso de Estudiantes de Doctorado en QuÃmica. , UNIVERSIDAD DE SEVILLA, - FACULTAD DE QUÃMICA. 2017
MartÃnez, Macarena;Moreno-Clavijo, Elena;Carmona-Asenjo, Ana Teresa;Moreno-Vargas, Antonio José;Robina-RamÃrez, Inmaculada;Matassini, Camilla;Cardona, Francesca:
Design, synthesis and biological evaluation of pyrrolidine multimeric iminosugars as glycosidase inhibitors. Comunicación en congreso. XIV Simposio de Investigadores Jóvenes Real Sociedad Española de QuÃmica-Merck. BADAJOZ (ESPAÑA). 2017
Design, synthesis and biological evaluation of pyrrolidine multimeric iminosugars as glycosidase inhibitors. Comunicación en congreso. XIV Simposio de Investigadores Jóvenes Real Sociedad Española de QuÃmica-Merck. BADAJOZ (ESPAÑA). 2017
MartÃnez, Macarena;ElÃas-RodrÃguez, Pilar;Pingitore, Valeria;Moreno-Vargas, Antonio José;Carmona-Asenjo, Ana Teresa;Robina-RamÃrez, Inmaculada;Moreno-Clavijo, Elena:
Click chemistry and in situ biological screening in the discovery of glycosidase inhibitors. Poster en Congreso. 26th International Society of Heterocyclic Chemistry Congress. REGENSBURG (ALEMANIA). 2017
Click chemistry and in situ biological screening in the discovery of glycosidase inhibitors. Poster en Congreso. 26th International Society of Heterocyclic Chemistry Congress. REGENSBURG (ALEMANIA). 2017
MartÃnez, Macarena;Moreno-Clavijo, Elena;Carmona-Asenjo, Ana Teresa;Moreno-Vargas, Antonio José;Robina-RamÃrez, Inmaculada;Matassini, Camilla;Cardona, Francesca:
Exploring the multivalent effect in glycosidase inhibition through pyrrolidine multimeric iminosugars . Poster en Congreso. 19th European Carbohydrate Symposium. Barcelona. 2017
Exploring the multivalent effect in glycosidase inhibition through pyrrolidine multimeric iminosugars . Poster en Congreso. 19th European Carbohydrate Symposium. Barcelona. 2017
MartÃnez, Macarena;ElÃas-RodrÃguez, Pilar;Moreno-Clavijo, Elena;Carmona-Asenjo, Ana Teresa;Moreno-Vargas, Antonio José;Robina-RamÃrez, Inmaculada:
Functionalized iminosugars as tunable scaffolds for the rapid discovery of glycosidase inhibitors via click chemistry-in situ biological . Poster en Congreso. 19th European Carbohydrate Symposium. Barcelona. 2017
Functionalized iminosugars as tunable scaffolds for the rapid discovery of glycosidase inhibitors via click chemistry-in situ biological . Poster en Congreso. 19th European Carbohydrate Symposium. Barcelona. 2017
MartÃnez, Macarena;Moreno-Clavijo, Elena;Carmona-Asenjo, Ana Teresa;Moreno-Vargas, Antonio José;Robina-RamÃrez, Inmaculada:
Application of CuAAC in the rapid discovery of selective glycosidase inhibitors. Comunicación en congreso. VI Iberian Carbohydrate Meeting. Viseu (Portugal). 2015
Application of CuAAC in the rapid discovery of selective glycosidase inhibitors. Comunicación en congreso. VI Iberian Carbohydrate Meeting. Viseu (Portugal). 2015
MartÃnez, Macarena;ElÃas-RodrÃguez, Pilar;Carmona-Asenjo, Ana Teresa;Moreno-Clavijo, Elena;Moreno-Vargas, Antonio José;Robina-RamÃrez, Inmaculada:
Generation of a library of (pyrrolidin-2-yl)triazoles and in situ screening as glycosidase inhibitors . Poster en Congreso. 7th Spanish Portuguese Japanese Organic Chemistry Symposium . Sevilla (España). 2015
Generation of a library of (pyrrolidin-2-yl)triazoles and in situ screening as glycosidase inhibitors . Poster en Congreso. 7th Spanish Portuguese Japanese Organic Chemistry Symposium . Sevilla (España). 2015
ArtÃculos publicados
Pingitore, Valeria;Moreno-Vargas, Antonio José;MartÃnez, Macarena;Carmona-Asenjo, Ana Teresa;Mészarós, Zuzana ;Kulik, Natalia;Slámová, Kristýna ;Kren, Vladimir;Bojarová, Pavla;Robina-RamÃrez, Inmaculada:
Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars. Bioorganic Chemistry. 2022. Vol: 120. doi.org/10.1016/j.bioorg.2022.105650 .
Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars. Bioorganic Chemistry. 2022. Vol: 120. doi.org/10.1016/j.bioorg.2022.105650 .
Velueta-viveros, Martha ;Padrón, José M.;Lopez-Lopez, Oscar;Fernandez-Bolaños-Guzman, Jose Maria;MartÃnez, Macarena;Puerta, Adrián;Romero-hernández, Laura L. ;Kren, Vladimir;Merino-montiel, Penélope ;Montiel-smith, Sara;Fernandes, Miguel X.;Moreno-Vargas, Antonio José:
Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer¿s disease. Bioorganic Chemistry. 2022. Vol: 127.
Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer¿s disease. Bioorganic Chemistry. 2022. Vol: 127.
Ortega-vidal, Juan;Cobo-Molinos, Antonio;Ortega-Morente, Elena;Gálvez Del Postigo-Ruiz, Antonio Miguel;MartÃnez, Macarena;Salido, SofÃa;Altarejos-Caballero, JoaquÃn:
Antimicrobial activity of phenolics isolated from the pruning wood residue of European plum (Prunus domestica L.). Industrial Crops and Products. 2022. Vol: 176. https://doi.org/10.1016/j.indcrop.2021.114296.
Antimicrobial activity of phenolics isolated from the pruning wood residue of European plum (Prunus domestica L.). Industrial Crops and Products. 2022. Vol: 176. https://doi.org/10.1016/j.indcrop.2021.114296.
MartÃnez, Macarena;Carmona-Asenjo, Ana Teresa;Cardona, Francesca;Matassini, Camilla;Goti, Andrea;Kubo, Moemi;Kato, Atsushi;Robina-RamÃrez, Inmaculada;Moreno-Vargas, Antonio José:
Synthesis of multimeric pyrrolidine iminosugar inhibitors of human ß-glucocerebrosidase and ¿-galactosidase A: First example of a multivalent enzyme a. European Journal of Medicinal Chemistry. 2020. Vol: 192. https://doi.org/10.1016/j.ejmech.2020.112173.
Synthesis of multimeric pyrrolidine iminosugar inhibitors of human ß-glucocerebrosidase and ¿-galactosidase A: First example of a multivalent enzyme a. European Journal of Medicinal Chemistry. 2020. Vol: 192. https://doi.org/10.1016/j.ejmech.2020.112173.
Clemente, F.;Cardona, F.;Matassini, C.;Faggi, C.;Giachetti, S.;Cresti, C.;Morrone, A.;Paoli, P.;Goti, A.;MartÃnez, Macarena:
Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: inhibition and pharmacological chaperoning. Bioorganic Chemistry. 2020. Vol: 98. https://doi.org/10.1016/j.bioorg.2020.103740.
Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: inhibition and pharmacological chaperoning. Bioorganic Chemistry. 2020. Vol: 98. https://doi.org/10.1016/j.bioorg.2020.103740.
Gil De Montes, Enrique;MartÃnez, Macarena;Carmona-Asenjo, Ana Teresa;Robina-RamÃrez, Inmaculada;Moreno-Vargas, Antonio José:
Regioselectivity of the 1,3-dipolar cycloaddition of organic azides to 7-heteronorbornadienes. Synthesis of ß-substituted furans/pyrroles. The Journal of Organic Chemistry. 2020. Vol: 85. Pág. 8923-8932. 10.1021/acs.joc.0c00810.
Regioselectivity of the 1,3-dipolar cycloaddition of organic azides to 7-heteronorbornadienes. Synthesis of ß-substituted furans/pyrroles. The Journal of Organic Chemistry. 2020. Vol: 85. Pág. 8923-8932. 10.1021/acs.joc.0c00810.
Monaco, Serena;Angulo-Ãlvarez, Jesús;Walpole, Samuel;Doukani, Hassan;Nepravishta, Ridvan;MartÃnez, Macarena;Carmona-Asenjo, Ana Teresa;Ramos-soriano, Javier;Bergstrom, Maria;Robina-RamÃrez, Inmaculada:
Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Po. Chemistry: A European Journal. 2020. https://doi.org/10.1002/chem.202001723.
Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Po. Chemistry: A European Journal. 2020. https://doi.org/10.1002/chem.202001723.
MartÃnez, Macarena;Carmona-Asenjo, Ana Teresa;Patterson-orazem, Athéna C;Lieberman, Raquel L.;Ide, Daisuke;Kubo, Moemi;Kato, Atsushi;Robina-RamÃrez, Inmaculada;Moreno-Vargas, Antonio José:
Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars:Structural basis of ß-glucocerebrosidase inhibition. Bioorganic Chemistry. 2019. Vol: 86. Pág. 652-664. 10.1016/j.bioorg.2019.02.025.
Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars:Structural basis of ß-glucocerebrosidase inhibition. Bioorganic Chemistry. 2019. Vol: 86. Pág. 652-664. 10.1016/j.bioorg.2019.02.025.
MartÃnez, Macarena;Galbis-Fuster, Elsa;Carmona-Asenjo, Ana Teresa;Paz-Bañez, Maria Violante De;Robina-RamÃrez, Inmaculada:
Preparation of water-soluble glycopolymers derived from five-membered iminosugars. European Polymer Journal. 2019. Vol: 119. Pág. 213-221. doi.org/10.1016/j.eurpolymj.2019.07.027.
Preparation of water-soluble glycopolymers derived from five-membered iminosugars. European Polymer Journal. 2019. Vol: 119. Pág. 213-221. doi.org/10.1016/j.eurpolymj.2019.07.027.
MartÃnez, Macarena;Moreno-Vargas, Antonio José;Jiménez-ortega, Elena;Carmona-Asenjo, Ana Teresa;Robina-RamÃrez, Inmaculada;Sanz-aparicio, Julia;Talens Perales, David;Polaina, Julio;Matassini, Camilla;Cardona, Francesca:
Structural basis of the inhibition of GH1 ß-glucosidases by multivalent pyrrolidine iminosugars. Bioorganic Chemistry. 2019. Vol: 89. doi.org/10.1016/j.bioorg.2019.103026.
Structural basis of the inhibition of GH1 ß-glucosidases by multivalent pyrrolidine iminosugars. Bioorganic Chemistry. 2019. Vol: 89. doi.org/10.1016/j.bioorg.2019.103026.
MartÃnez, Macarena;Carmona-Asenjo, Ana Teresa;Moreno-Clavijo, Elena;Robina-RamÃrez, Inmaculada;Ide, Daisuke;Kato, Atsushi;Moreno-Vargas, Antonio José:
Tuning of beta-glucosidase and alpha-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecule. European Journal of Medicinal Chemistry. 2017. Vol: 138. Pág. 532-542.
Tuning of beta-glucosidase and alpha-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecule. European Journal of Medicinal Chemistry. 2017. Vol: 138. Pág. 532-542.
